African Union (joined in 1963). The African Union has various decision-making institutions, among which: the Assembly of Heads of State and Government, the Executive Council, the Permanent Representatives Committee, the Peace and Security Council, the African Union Commission and the Pan-African Parliament. The African Union aims to further the development of the member states through collaboration and solidarity. This entails promotion of peace, economic development, human rights and democracy. The Specialised Technical Committee on Migration, Refugees and Internally Displaced Persons is a crucial instrument of the African Union to ensure protection and assistance to these key populations.

The Economic Community of Central African States (ECCAS) (joined in 1966). Its main institutions are the Conference of Heads of State and Government and the Council of Ministers. Its executive body since the institutional reform of 2019 is the Commission. ECCAS has defined several missions, including guaranteeing peace and security within the region through political cooperation; economic and financial integration through the establishment of a common market and the free movement of goods, capital and services within the regiona ; physical integration through the development of infrastructure and land-use planning, such as road, rail, air and sea links, to create a common space and promote the free movement of people, goods and services; and social and human development integration to eliminate poverty in all its forms.

The African and Malagasy Council for Higher Education (CAMES) (joined in 1968). Its supreme body is the Council of Ministers, which meets once a year in ordinary session. Its executive body is the General Secretariat, whose Secretary General is appointed by the Council of Ministers. CAMES aims to promote cooperation in research and higher education between member states, notably through a system of diploma equivalence.

Economic and Monetary Community of Central Africa (CEMAC) (joined in 1999). CEMAC was created to promote economic integration, notably through the creation of a common market favoring the free circulation of people, goods and capital, and the existence of a common currency. CEMAC also aims to support development and peace in the region. CEMAC is made up of a number of bodies and institutions, four of which have decision-making powers: the Conference of Heads of State, the Council of Ministers of the Central African Economic Union, the Ministerial Committee of the Central African Monetary Union, and the Commission.